Anafranil ™ (clomipramine hydrochloride) Capsules USP is an antiobsessional medicine that concerns the course (dibenzazepine) of pharmacologic representatives recognized as tricyclic antidepressants. Anafranil is available as capsules of 25, 50, as well as 75 mg for dental administration.

Clomipramine hydrochloride USP is 3-chloro-5- [3-(dimethylamino) propyl] -10, 11-dihydro-5H-dibenz [b, f] azepine monohydrochloride, and also its structural formula is.

Clomipramine hydrochloride USP is a white to off-white crystalline powder. It is easily dissolvable in water, in methanol, and also in methylene chloride, and also insoluble in ethyl ether and also in hexane.

Non-active Ingredients. D&C Red No. 33 (25 mg pills simply), D&C Yellow No. 10, FD&C Blue No. 1 (50 milligrams capsules simply), FD&C Yellow No. 6, jelly, magnesium mineral stearate, methylparaben, propylparaben, carbohydrate (corn), and titanium dioxide.

Clomipramine (CMI) is assumed to influence obsessive and also uncontrollable actions through its effects on serotonergic neuronal transmission. The actual neurochemical mechanism is unknown, yet CMI's capacity to hinder the reuptake of serotonin (5-HT) is believed to be essential.

Absorption/Bioavailability-- CMI from Anafranil pills is as bioavailable as CMI from a solution. The bioavailability of CMI from pills is not considerably affected by meals.

In a dosage proportionality study entailing multiple CMI doses, steady-state plasma focus (Css) as well as area-under-plasma-concentration-time contours (AUC) of CMI and also CMI's major energetic metabolite, (DMI), were not proportional to dose over the varieties assessed, i. e. between 25 to 100 mg/day and also between 25 to 150 mg/day, although Css as well as AUC are about linearly associated to dose between 100 to 150 mg/day. The partnership between dose and also CMI/DMI focus at higher day-to-day doses has not been methodically assessed, but if there is considerable dose dependence at dosages over 150 mg/day, there is the capacity for significantly higher Css and AUC even for people dosed within the advised range. This could pose a potential risk to some individuals (view PRECAUTIONS and cautions, Drug Interactions). © All rights reserved 2011